The following list of medical aplications is not recognized by every government and is not allowed to be seen as officially approved medicinal standards, although we here at CBD Portal believe that the tens of thousands anecdotes and 1000’s of scientists, doctors and politicians who strongly believe in a future for Cannabinoid based medication, can not be wrong, and firmly believe in its medicinal potential

CBD Products | What is the difference

Medicine is basically given based on their target (internal, external etc.) and mode of action desired, so if one wants a medicine for stomach, it makes sense to give a capsule which can then directly go to stomach and act. This works if you have direct access to the organ desired, like stomach, Intestines, mouth (through orally solvable capsules, tablets, tincture, paste or edibles), skin (through ointments, salves etc.).

CBD Capsules

capsules cbdSince their inception, capsules have been viewed by consumers as the most efficient method of taking medication.

Capsules are easier to swallow and are used by manufacturers when the drug cannot be compacted into a solid tablet, it is normally a shell or container made of gelatin that contains the drug.

NutraHemp Corp.CBD Capsules

CBD Essence capsules from NutraCann offer a high CBD content per capsule, extracted from Hemp which is organically harvested in the EU.

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CBD Oil

dosingCBD, or Cannabinoid based oils, benefit from a direct intake by your body when applied.

Some CBD oil is made specifically for digestion, where other CBD oils are used topically (directly applied to the skin) in the form of lotions, ointments or salves

CBD Paste

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CBD E-Cigarettes

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CBD Edibles

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CBD Salve

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Back to your Endocannabinoid system

The endocannabinoid system is involved with many basic functions. It is believed to play a role in memory, mood, sleep, appetite, pain and immune response. It also affects a number of physiological processes including circulation, energy metabolism and organ function.

Besides maintaining basic functions, the endocannabinoid system acts in response to illness. For example, tumor cells have been shown to express more cannabinoid receptors than healthy cells. Studies also show a rise in endocannabinoid levels in patients with disorders such as arthritis and Parkinson’s disease.

davinci cbdAs a result, some scientists believe the overall function of this system is to regulate homeostasis.

Homeostasis is a key element in the biology of all living things. It is best described as the ability to maintain stable internal conditions that are necessary for survival. Disease is a result of a failure in achieving homeostasis.

The endocannabinoid system’s role in maintaining homeostasis make CBD products a unique and promising target in medicine

CBD | Lets get technical

Cannabidiol (CBD) is one of at least 85 active cannabinoids identified in Cannabis. It is a major phytocannabinoid, accounting for up to 40% of the plant’s extract. CBD is considered to have a wider scope of potential medical applications than tetrahydrocannabinol (THC).

Pharmaceutical preparations

Nabiximols (USAN, trade name Sativex) is an aerosolized mist for oral administration containing a near 1:1 ratio of CBD and THC. The drug was approved by Canadian authorities in 2005 to alleviate pain associated with multiple sclerosis.

Epidiolex is an oil formulation of CBD extracted from the cannabis plant undergoing clinical trials for refractory epilepsy syndromes

Pharmacodynamics

Cannabidiol has a very low affinity for CB1 and CB2 receptors but acts as an indirect antagonist of their agonists. While one would assume that this would cause cannabidiol to reduce the effects of THC, it may potentiate THC’s effects by increasing CB1 receptor density or through another CB1-related mechanism. It may also extend the duration of the effects of THC via inhibition of the cytochrome P-450-3A and 2C enzymes.

Recently, it was found to be an antagonist at the putative new cannabinoid receptor, GPR55, a GPCR expressed in thecaudate nucleus and putamen. Cannabidiol has also been shown to act as a 5-HT1A receptor partial agonist,[33] an action which may be involved in its antidepressant, anxiolytic, and neuroprotective effects. Cannabidiol is an allosteric modulator of μ and δ-opioid receptors. Cannabidiol’s pharmacological effects have also been attributed to PPAR-γ receptor agonism and intracellular calcium release.

Research suggests that CBD may exert some of its pharmacological action through its inhibition of FAAH, which may in turn increase the levels of endocannabinoids, such as anandamide, produced by the body.

Pharmacodynamics

Scientific and clinical research—much of it sponsored by the US government—underscores CBD’s potential as a treatment for a wide range of conditions, including arthritis, diabetes, alcoholism, MS, chronic pain, schizophrenia, PTSD, depression, antibiotic-resistant infections, epilepsy, and other neurological disorders. CBD has demonstrable neuroprotective and neurogenic effects, and its anti-cancer properties are currently being investigated at several academic research centers in the United States and elsewhere.